6c0b

X-ray diffraction
2.5Å resolution

Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
PDBe Complex ID:
PDB-CPX-148301 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Toxin B Chain: A
Molecule details ›
Chain: A
Length: 522 amino acids
Theoretical weight: 59.02 KDa
Source organism: Clostridioides difficile
Expression system: Escherichia coli
UniProt:
  • Canonical: P18177 (Residues: 1285-1804; Coverage: 22%)
Gene names: tcdB, toxB
Sequence domains: TcdA/TcdB pore forming domain
Frizzled-2 Chain: B
Molecule details ›
Chain: B
Length: 156 amino acids
Theoretical weight: 17.45 KDa
Source organism: Homo sapiens
Expression system: Mammalia
UniProt:
  • Canonical: Q14332 (Residues: 34-156; Coverage: 23%)
Gene name: FZD2
Sequence domains: Fz domain
Structure domains: Frizzled cysteine-rich domain

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2221
Unit cell:
a: 74.611Å b: 175.613Å c: 174.423Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.199 0.237
Expression systems:
  • Escherichia coli
  • Mammalia