› 6c5q

X-ray diffraction
2.4Å resolution

PPARg LBD bound to SR10171

Released:
DOI: 10.2210/pdb6c5q/pdb
PDB entry 6c5q coloured by chain, front view.
PDB entry 6c5q coloured by chain, side view.
PDB entry 6c5q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix.
Frkic RL, Marshall AC, Blayo AL, Pukala TL, Kamenecka TM, Griffin PR, Bruning JB
iScience 5 69-79 (2018)
PMID: 30123887

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 281 amino acids
Theoretical weight: 32.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 235-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand EKS 2 x EKS
1 modified residue:
Ligand CSO 1 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P6522
Unit cell:
a: 65.19Å b: 65.19Å c: 368.45Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.25 0.249 0.277
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer.
Chai et al. (2020)
4 more

3 mentions without citation

PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix.
Frkic et al. (2018)
2 more