Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110368 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase JAK1
Molecule details ›
Chain: A
Length: 286 amino acids
Theoretical weight: 32.94 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
Length: 286 amino acids
Theoretical weight: 32.94 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P23458 (Residues: 869-1153; Coverage: 25%)
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
Suppressor of cytokine signaling 1
Molecule details ›
Chain: B
Length: 117 amino acids
Theoretical weight: 13.16 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: SH2 domain
Length: 117 amino acids
Theoretical weight: 13.16 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: B6RCQ2 (Residues: 48-164; Coverage: 57%)
Sequence domains: SH2 domain
