› 6cd6

X-ray diffraction
2.2Å resolution

Crystal Structure of the Human CAMKK1A in complex with GSK650394

Released:
DOI: 10.2210/pdb6cd6/pdb
PDB entry 6cd6 coloured by chain, front view.
PDB entry 6cd6 coloured by chain, side view.
PDB entry 6cd6 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Santiago AS, Counago RM, Righetto GL, Ramos PZ, Silva PNB, Drewry D, Elkins JM, Massirer KB, Arruda P, Edwards AM, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185406 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase kinase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 290 amino acids
Theoretical weight: 32.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8N5S9 (Residues: 124-411; Coverage: 57%)
Gene names: CAMKK1, CAMKKA
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand DXV 4 x DXV
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 44.378Å b: 96.042Å c: 141.26Å
α: 90° β: 90.03° γ: 90°
R-values:
R R work R free
0.235 0.232 0.285
Expression system: Escherichia coli BL21(DE3)

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