› 6cdf

X-ray diffraction
2.6Å resolution

Human CtBP1 (28-378)

Released:
DOI: 10.2210/pdb6cdf/pdb
PDB entry 6cdf coloured by chain, front view.
PDB entry 6cdf coloured by chain, side view.
PDB entry 6cdf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Assembly of human C-terminal binding protein (CtBP) into tetramers.
Bellesis AG, Jecrois AM, Hayes JA, Schiffer CA, Royer WE
J Biol Chem 293 9101-9112 (2018)
PMID: 29700119

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171656 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-terminal-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 373 amino acids
Theoretical weight: 40.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13363 (Residues: 28-379; Coverage: 80%)
Gene names: CTBP, CTBP1
Sequence domains:
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

3 bound ligands:
Ligand NAI 1 x NAI
Ligand CA 1 x CA
Ligand FMT 1 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P6422
Unit cell:
a: 88.657Å b: 88.657Å c: 163.914Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.207 0.244
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The transrepression and transactivation roles of CtBPs in the pathogenesis of different diseases.
Chen et al. (2021)
22 other articles

2 mentions without citation

Assembly of human C-terminal binding protein (CtBP) into tetramers.
Bellesis et al. (2018)
1 more