› 6cej

Solution NMR

Solution structure of a 14mer fragment of the p21 protein

Released:
DOI: 10.2210/pdb6cej/pdb
PDB entry 6cej coloured by chain, ensemble of 20 models, front view.
PDB entry 6cej coloured by chain, ensemble of 20 models, side view.
PDB entry 6cej coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Rational Design of a 310 -Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.
Wegener KL, McGrath AE, Dixon NE, Oakley AJ, Scanlon DB, Abell AD, Bruning JB
Chemistry 24 11325-11331 (2018)
PMID: 29917264

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153777 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 14 amino acids
Theoretical weight: 1.79 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P38936 (Residues: 139-152; Coverage: 9%)
Gene names: CAP20, CDKN1, CDKN1A, CIP1, MDA6, PIC1, SDI1, WAF1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 41%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

2 review citations

Targeting Non-Oncogene Addiction for Cancer Therapy.
Chang et al. (2021)
1 more