› 6chw

X-ray diffraction
1.89Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136919 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 28.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 306-551; Coverage: 41%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

3 bound ligands:
Ligand F3D 1 x F3D
Ligand EDO 3 x EDO
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P6522
Unit cell:
a: 58.735Å b: 58.735Å c: 274.814Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.2 0.257
Expression system: Escherichia coli

Quick links

Citations

24 review citations

Recent advances in breast cancer research impacting clinical diagnostic practice.
McCart Reed et al. (2019)
23 more

6 mentions without citation

Computer-Aided Ligand Discovery for Estrogen Receptor Alpha.
Bafna et al. (2020)
5 more