› 6chz

X-ray diffraction
1.68Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136919 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 30.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 307-554; Coverage: 42%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand F3D 1 x F3D
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P6522
Unit cell:
a: 58.608Å b: 58.608Å c: 276.303Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.215 0.212 0.262
Expression system: Escherichia coli

Quick links

Citations

27 review citations

Endocrine Resistance in Hormone Receptor Positive Breast Cancer-From Mechanism to Therapy.
Rani et al. (2019)
26 more

6 mentions without citation

Comparison of Data Fusion Methods as Consensus Scores for Ensemble Docking.
Bajusz et al. (2019)
5 more