› 6cnm

Electron Microscopy
3.4Å resolution

Cryo-EM structure of the human SK4/calmodulin channel complex

Released:
DOI: 10.2210/pdb6cnm/pdb
PDB entry 6cnm coloured by chain, front view.
PDB entry 6cnm coloured by chain, side view.
PDB entry 6cnm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.
Lee CH, MacKinnon R
Science 360 508-513 (2018)
PMID: 29724949
Related structures: EMD-7537

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127535 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Intermediate conductance calcium-activated potassium channel protein 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 427 amino acids
Theoretical weight: 47.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15554 (Residues: 1-427; Coverage: 100%)
Gene names: IK1, IKCA1, KCA4, KCNN4, SK4
Sequence domains:
Calmodulin-1 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DP23 (Residues: 1-149; Coverage: 100%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

3 bound ligands:
Ligand K 5 x K
Ligand POV 4 x POV
Ligand LMT 8 x LMT
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-7537
Expression system: Homo sapiens

Quick links

Citations

27 review citations

Physiological Roles and Therapeutic Potential of Ca2+ Activated Potassium Channels in the Nervous System.
Kshatri et al. (2018)
26 more

12 mentions without citation

Molecular Choreography and Structure of Ca2+ Release-Activated Ca2+ (CRAC) and KCa2+ Channels and Their Relevance in Disease with Special Focus on Cancer.
Tiffner et al. (2020)
11 more