› 6cq7

X-ray diffraction
2Å resolution

The SH3 domain of MLK3 in complex with poly-proline peptide derived from Htt

Released:
DOI: 10.2210/pdb6cq7/pdb
PDB entry 6cq7 coloured by chain, front view.
PDB entry 6cq7 coloured by chain, side view.
PDB entry 6cq7 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kall SL, Lavie A

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-172515 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase 11 Chain: A
Molecule details ›
Chain: A
Length: 80 amino acids
Theoretical weight: 8.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16584 (Residues: 41-108; Coverage: 8%)
Gene names: MAP3K11, MLK3, PTK1, SPRK
Sequence domains: Variant SH3 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P4322
Unit cell:
a: 59Å b: 59Å c: 84.36Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.196 0.26
Expression system: Escherichia coli

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