Function and Biology Details
Reaction catalysed:
Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Biotin/lipoyl attachment
- Peripheral subunit-binding domain
- E3-binding domain superfamily
- 2-oxo acid dehydrogenase, lipoyl-binding site
- Single hybrid motif
- 2-oxoacid dehydrogenase acyltransferase, catalytic domain
- Chloramphenicol acetyltransferase-like domain superfamily
- Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component
1 more domain
Structure analysis Details
Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145330 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Molecule details ›
Chain: 0
Length: 647 amino acids
Theoretical weight: 69.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 647 amino acids
Theoretical weight: 69.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P10515 (Residues: 1-647; Coverage: 100%)
Sequence domains:
