› 6ct2

X-ray diffraction
2.13Å resolution

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190669 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT8 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 34.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H7Z6 (Residues: 174-449; Coverage: 60%)
Gene names: KAT8, MOF, MYST1, PP7073
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand FCV 1 x FCV
Ligand ZN 1 x ZN
Ligand MG 1 x MG
1 modified residue:
Ligand ALY 1 x ALY

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 45.892Å b: 56.08Å c: 120.919Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.2 0.236
Expression system: Escherichia coli

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Citations

43 review citations

Hepatocellular Senescence: Immunosurveillance and Future Senescence-Induced Therapy in Hepatocellular Carcinoma.
Liu et al. (2020)
42 more

1 mention without citation

First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8.
Fiorentino et al. (2023)