› 6cu7

Electron Microscopy
3.5Å resolution

Alpha Synuclein fibril formed by full length protein - Rod Polymorph

Released:
DOI: 10.2210/pdb6cu7/pdb
PDB entry 6cu7 coloured by chain, front view.
PDB entry 6cu7 coloured by chain, side view.
PDB entry 6cu7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel.
Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L
Nat Commun 9 3609 (2018)
PMID: 30190461
Related structures: EMD-7618

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153502 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-synuclein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 140 amino acids
Theoretical weight: 14.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37840 (Residues: 1-140; Coverage: 100%)
Gene names: NACP, PARK1, SNCA
Sequence domains: Synuclein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-7618
Expression system: Escherichia coli

Quick links

Citations

72 review citations

Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles.
Meade et al. (2019)
71 more

40 mentions without citation

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis.
Nguyen et al. (2021)
39 more