› 6d03

Electron Microscopy
3.68Å resolution

Cryo-EM structure of a Plasmodium vivax invasion complex essential for entry into human reticulocytes; one molecule of parasite ligand.

Released:
DOI: 10.2210/pdb6d03/pdb
PDB entry 6d03 coloured by chain, front view.
PDB entry 6d03 coloured by chain, side view.
PDB entry 6d03 coloured by chain, top view.
Source organisms:
Primary publication:
Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Gruszczyk J, Huang RK, Chan LJ, Menant S, Hong C, Murphy JM, Mok YF, Griffin MDW, Pearson RD, Wong W, Cowman AF, Yu Z, Tham WH
Nature 559 135-139 (2018)
PMID: 29950717
Related structures: EMD-7783

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-107675 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Transferrin receptor protein 1, serum form Chains: A, B
Molecule details ›
Chains: A, B
Length: 659 amino acids
Theoretical weight: 73.94 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P02786 (Residues: 121-760; Coverage: 84%)
Gene name: TFRC
Sequence domains:
Structure domains:
Serotransferrin Chains: C, D
Molecule details ›
Chains: C, D
Length: 698 amino acids
Theoretical weight: 77.15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02787 (Residues: 1-698; Coverage: 100%)
Gene names: PRO1400, TF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II
NBD94 domain-containing protein Chain: E
Molecule details ›
Chain: E
Length: 820 amino acids
Theoretical weight: 96.8 KDa
Source organism: Plasmodium vivax Sal-1
Expression system: Escherichia coli
UniProt:
  • Canonical: A5K736 (Residues: 2-815; Coverage: 31%)
Gene name: PVX_094255

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand CA 2 x CA
Ligand NAG 4 x NAG
Ligand FE 4 x FE
Ligand CO3 4 x CO3
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.68Å
Relevant EMDB volumes: EMD-7783
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli

Quick links

Citations

9 review citations

Plasmodium vivax Duffy Binding Protein-Based Vaccine: a Distant Dream.
Kar et al. (2022)
8 more

6 mentions without citation

Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase.
Rusnac et al. (2018)
5 more