› 6dcn

X-ray diffraction
2.44Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero tetramer (preferred)
hetero octamer
Assembly name:
PDBe Complex ID:
PDB-CPX-170526 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-like protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 156 amino acids
Theoretical weight: 17.7 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q07817 (Residues: 1-208; Coverage: 65%)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:
Beclin-1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 26 amino acids
Theoretical weight: 2.93 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q14457 (Residues: 105-130; Coverage: 6%)
Gene names: BECN1, GT197
Sequence domains: Beclin-1 BH3 domain, Bcl-2-interacting

Ligands and Environments

No bound ligands
1 modified residue:
Ligand TPO 2 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P4212
Unit cell:
a: 109.419Å b: 109.419Å c: 97.127Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.189 0.229
Expression system: Not provided

Quick links

Citations

9 review citations

The role of cell signaling in the crosstalk between autophagy and apoptosis in the regulation of tumor cell survival in response to sorafenib and neratinib.
Booth et al. (2020)
8 more

4 mentions without citation

The Structural Biology of Bcl-xL.
Lee et al. (2019)
3 more