› 6dcv

X-ray diffraction
1.9Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134615 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Immunoglobulin kappa constant Chains: A, L
Molecule details ›
Chains: A, L
Length: 220 amino acids
Theoretical weight: 24.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Immunoglobulin heavy constant gamma 1 Chains: B, H
Molecule details ›
Chains: B, H
Length: 231 amino acids
Theoretical weight: 24.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 1-107; Coverage: 27%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

1 bound ligand:
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2
Unit cell:
a: 93.411Å b: 60.578Å c: 169.472Å
α: 90° β: 103.52° γ: 90°
R-values:
R R work R free
0.188 0.186 0.229
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Intersection of pathological tau and microglia at the synapse.
Vogels et al. (2019)
1 more