› 6dcw

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-104310 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin kappa constant Chain: L
Molecule details ›
Chain: L
Length: 220 amino acids
Theoretical weight: 24.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Immunoglobulin heavy constant gamma 1 Chain: H
Molecule details ›
Chain: H
Length: 231 amino acids
Theoretical weight: 24.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 1-107; Coverage: 27%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Microtubule-associated protein Chain: T
Molecule details ›
Chain: T
Length: 20 amino acids
Theoretical weight: 2.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: A0A2K5IAM2 (Residues: 543-562; Coverage: 3%)
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: C2
Unit cell:
a: 92.308Å b: 59.67Å c: 82.331Å
α: 90° β: 103.62° γ: 90°
R-values:
R R work R free
0.17 0.168 0.216
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

2 review citations

Intersection of pathological tau and microglia at the synapse.
Vogels et al. (2019)
1 more