6df3

X-ray diffraction
2.15Å resolution

Crystal structure of ternary complex of IL-24 with soluble receptors IL-22RA and IL-20RB

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-171500 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Interleukin-22 receptor subunit alpha-1 Chain: L
Molecule details ›
Chain: L
Length: 206 amino acids
Theoretical weight: 23.56 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q8N6P7 (Residues: 24-228; Coverage: 37%)
Gene names: IL22R, IL22RA1
Sequence domains: Tissue factor
Structure domains: Immunoglobulins
Interleukin-24 Chain: C
Molecule details ›
Chain: C
Length: 155 amino acids
Theoretical weight: 18.2 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q13007 (Residues: 52-206; Coverage: 100%)
Gene names: IL24, MDA7, ST16
Interleukin-20 receptor subunit beta Chain: H
Molecule details ›
Chain: H
Length: 190 amino acids
Theoretical weight: 21.37 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q6UXL0 (Residues: 35-224; Coverage: 67%)
Gene names: DIRS1, IL20RB, UNQ557/PRO1114
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43
Unit cell:
a: 77.702Å b: 77.702Å c: 124.785Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.225
Expression system: Drosophila melanogaster