Function and Biology Details
Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Small GTPase superfamily, ARF/SAR type
- Clathrin adaptor, mu subunit
- HIV-1 Nef protein, core domain superfamily
- HIV negative factor Nef
- P-loop containing nucleoside triphosphate hydrolase
- Adaptor protein complex, sigma subunit
- Mu homology domain
- Clathrin adaptor, mu subunit, conserved site
15 more domains
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-149825 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Bone marrow stromal antigen 2; Protein Nef
Molecule details ›
Chains: L, T
Length: 264 amino acids
Theoretical weight: 29.96 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
Sequence domains: Negative factor, (F-Protein) or Nef
Length: 264 amino acids
Theoretical weight: 29.96 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
- Canonical:
Q10589 (Residues: 2-21; Coverage: 11%) - Canonical: Q90VU7 (Residues: 1-206; Coverage: 100%)
Sequence domains: Negative factor, (F-Protein) or Nef
AP-1 complex subunit beta-1
Molecule details ›
Chain: B
Length: 586 amino acids
Theoretical weight: 66.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Adaptin N terminal region
Structure domains: Leucine-rich Repeat Variant
Length: 586 amino acids
Theoretical weight: 66.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q10567 (Residues: 1-584; Coverage: 62%)
Sequence domains: Adaptin N terminal region
Structure domains: Leucine-rich Repeat Variant
ADP-ribosylation factor 1
Molecule details ›
Chains: C, H
Length: 193 amino acids
Theoretical weight: 22.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: ADP-ribosylation factor family
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Length: 193 amino acids
Theoretical weight: 22.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P84077 (Residues: 17-181; Coverage: 91%)
Sequence domains: ADP-ribosylation factor family
Structure domains: P-loop containing nucleotide triphosphate hydrolases
AP-1 complex subunit gamma-1
Molecule details ›
Chain: G
Length: 601 amino acids
Theoretical weight: 68.19 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Sequence domains: Adaptin N terminal region
Structure domains: Leucine-rich Repeat Variant
Length: 601 amino acids
Theoretical weight: 68.19 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical: P22892 (Residues: 1-595; Coverage: 72%)
Sequence domains: Adaptin N terminal region
Structure domains: Leucine-rich Repeat Variant
AP-1 complex subunit mu-1
Molecule details ›
Chain: M
Length: 423 amino acids
Theoretical weight: 48.61 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains: Beta-Lactamase
Length: 423 amino acids
Theoretical weight: 48.61 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical: P35585 (Residues: 1-423; Coverage: 100%)
Sequence domains:
Structure domains: Beta-Lactamase
AP-1 complex subunit sigma-3
Molecule details ›
Chain: S
Length: 154 amino acids
Theoretical weight: 18.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Clathrin adaptor complex small chain
Structure domains: Beta-Lactamase
Length: 154 amino acids
Theoretical weight: 18.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q96PC3 (Residues: 1-154; Coverage: 100%)
Sequence domains: Clathrin adaptor complex small chain
Structure domains: Beta-Lactamase
