› 6djs

Electron Microscopy
5.8Å resolution

Hybrid model of TRPC3 in GDN

Released:
DOI: 10.2210/pdb6djs/pdb
PDB entry 6djs coloured by chain, front view.
PDB entry 6djs coloured by chain, side view.
PDB entry 6djs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating.
Sierra-Valdez F, Azumaya CM, Romero LO, Nakagawa T, Cordero-Morales JF
J Biol Chem 293 16102-16114 (2018)
PMID: 30139744
Related structures: EMD-7940

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171729 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Short transient receptor potential channel 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 676 amino acids
Theoretical weight: 68.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13507 (Residues: 73-384, 846-921; Coverage: 42%)
Gene names: TRP3, TRPC3
Sequence domains: Transient receptor ion channel II

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.8Å
Relevant EMDB volumes: EMD-7940
Expression system: Spodoptera frugiperda

Quick links

Citations

9 review citations

TRPC channels: Structure, function, regulation and recent advances in small molecular probes.
Wang et al. (2020)
8 more

3 mentions without citation

Recent advances in our understanding of the structure and function of more unusual cation channels.
Brown et al. (2019)
2 more