› 6dqz

Electron Microscopy
6.01Å resolution

Class 4 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor

Released:
DOI: 10.2210/pdb6dqz/pdb
PDB entry 6dqz coloured by chain, front view.
PDB entry 6dqz coloured by chain, side view.
PDB entry 6dqz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the regulation of inositol trisphosphate receptors by Ca2+ and IP3.
Paknejad N, Hite RK
Nat Struct Mol Biol 25 660-668 (2018)
PMID: 30013099
Related structures: EMD-7986

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172038 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol 1,4,5-trisphosphate receptor type 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 2671 amino acids
Theoretical weight: 304.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q14573 (Residues: 1-2671; Coverage: 100%)
Gene name: ITPR3
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 4 x ZN
Ligand I3P 4 x I3P
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 6.01Å
Relevant EMDB volumes: EMD-7986
Expression system: Homo sapiens

Quick links

Citations

19 review citations

Bcl-2-Protein Family as Modulators of IP3 Receptors and Other Organellar Ca2+ Channels.
Ivanova et al. (2020)
18 more

1 mention without citation

Structural basis for the regulation of inositol trisphosphate receptors by Ca2+ and IP3.
Paknejad et al. (2018)