› 6drw

X-ray diffraction
2.3Å resolution

JAK2 JH1 in complex with JNJ-7706621 (Crystal Form 2)

Released:
DOI: 10.2210/pdb6drw/pdb
PDB entry 6drw coloured by chain, front view.
PDB entry 6drw coloured by chain, side view.
PDB entry 6drw coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Puleo DE, Schlessinger J

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130063 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK2 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 37.4 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60674 (Residues: 840-1132; Coverage: 26%)
Gene name: JAK2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SKE 1 x SKE
1 modified residue:
Ligand PTR 1 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 107.867Å b: 69.042Å c: 50.05Å
α: 90° β: 99.07° γ: 90°
R-values:
R R work R free
0.216 0.214 0.255
Expression system: Spodoptera frugiperda

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