6e1h

Electron Microscopy
3.5Å resolution

Structure of 2:1 human Ptch1-Shh-N complex

Released:
Source organism: Homo sapiens
Related structures: EMD-8955

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-171800 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein patched homolog 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1447 amino acids
Theoretical weight: 160.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13635 (Residues: 1-1447; Coverage: 100%)
Gene names: PTCH, PTCH1
Sequence domains: Patched family
Sonic hedgehog protein N-product Chain: C
Molecule details ›
Chain: C
Length: 174 amino acids
Theoretical weight: 19.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15465 (Residues: 24-197; Coverage: 40%)
Gene name: SHH
Sequence domains: Hedgehog amino-terminal signalling domain
Structure domains: Muramoyl-pentapeptide Carboxypeptidase; domain 2

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-8955
Expression system: Homo sapiens