› 6e26

Solution NMR

NMR solution structure of the CARD9 CARD

Released:
DOI: 10.2210/pdb6e26/pdb
PDB entry 6e26 coloured by chain, ensemble of 20 models, front view.
PDB entry 6e26 coloured by chain, ensemble of 20 models, side view.
PDB entry 6e26 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
Holliday MJ, Ferrao R, de Leon Boenig G, Estevez A, Helgason E, Rohou A, Dueber EC, Fairbrother WJ
J Biol Chem 293 16803-16817 (2018)
PMID: 30206119

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190536 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caspase recruitment domain-containing protein 9 Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 11.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H257 (Residues: 1-97; Coverage: 18%)
Gene name: CARD9
Sequence domains: Caspase recruitment domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 92%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

The Role of CARD9 in Metabolic Diseases.
Tian et al. (2020)
2 more

4 mentions without citation

Assembly of platforms for signal transduction in the new era: dimerization, helical filament assembly, and beyond.
Ha et al. (2020)
3 more