› 6e28

X-ray diffraction
1.36Å resolution

The CARD9 CARD domain-swapped dimer

Released:
DOI: 10.2210/pdb6e28/pdb
PDB entry 6e28 coloured by chain, front view.
PDB entry 6e28 coloured by chain, side view.
PDB entry 6e28 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
Holliday MJ, Ferrao R, de Leon Boenig G, Estevez A, Helgason E, Rohou A, Dueber EC, Fairbrother WJ
J Biol Chem 293 16803-16817 (2018)
PMID: 30206119

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190538 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caspase recruitment domain-containing protein 9 Chains: C, D
Molecule details ›
Chains: C, D
Length: 97 amino acids
Theoretical weight: 11.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H257 (Residues: 2-97; Coverage: 18%)
Gene name: CARD9
Sequence domains: Caspase recruitment domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 43.98Å b: 37.43Å c: 56.88Å
α: 90° β: 101.47° γ: 90°
R-values:
R R work R free
0.18 0.18 0.194
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

CARD9 Signaling, Inflammation, and Diseases.
Liu et al. (2022)
2 more

2 mentions without citation

The adaptor protein CARD9, from fungal immunity to tumorigenesis.
Wang et al. (2020)
1 more