Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130064 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase JAK2
Molecule details ›
Chains: A, B, C, D
Length: 483 amino acids
Theoretical weight: 55.81 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 483 amino acids
Theoretical weight: 55.81 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
O60674 (Residues: 36-514; Coverage: 42%)
Sequence domains:
Erythropoietin receptor
Molecule details ›
Chains: M, N, O, P
Length: 83 amino acids
Theoretical weight: 8.94 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Length: 83 amino acids
Theoretical weight: 8.94 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: P19235 (Residues: 273-338; Coverage: 14%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ALS BEAMLINE 5.0.1
Spacegroup:
C2
Expression system: Trichoplusia ni
