› 6e35

X-ray diffraction
2.41Å resolution

Crystal structure of human indoleamime 2,3-dioxygenase (IDO1) in complex with L-Trp and cyanide, Northeast Structural Genomics Target HR6160

Released:
DOI: 10.2210/pdb6e35/pdb
PDB entry 6e35 coloured by chain, front view.
PDB entry 6e35 coloured by chain, side view.
PDB entry 6e35 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Forouhar F, Lewis-Ballester A, Lew S, Karkashon S, Seetharaman J, Lu C, Hussain M, Yeh S-R, Tong L, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Reaction catalysed: 
D-tryptophan + O(2) = N-formyl-D-kynurenine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147134 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Indoleamine 2,3-dioxygenase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 425 amino acids
Theoretical weight: 47.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P14902 (Residues: 11-403; Coverage: 98%)
Gene names: IDO, IDO1, INDO
Sequence domains: Indoleamine 2,3-dioxygenase

Ligands and Environments


Cofactor: Ligand HEM 2 x HEM
3 bound ligands:
Ligand CYN 2 x CYN
Ligand TRP 2 x TRP
Ligand ZCW 1 x ZCW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P212121
Unit cell:
a: 85.77Å b: 90.302Å c: 136.766Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.182 0.236
Expression system: Homo sapiens

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