Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- WD40 repeat
- Guanine nucleotide binding protein (G-protein), alpha subunit
- GPCR, family 2, calcitonin receptor family
- GPCR, family 2, secretin-like
- GPCR, family 2, calcitonin gene-related peptide, type 1 receptor
- G-protein alpha subunit, group S
- Calcitonin gene-related peptide
- G-protein gamma-like domain
25 more domains
Structure analysis Details
Assembly composition:
hetero heptamer (preferred)
Assembly name:
CGRP receptor complex (preferred)
PDBe Complex ID:
PDB-CPX-208112 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (7 distinct):
Calcitonin gene-related peptide 1
Molecule details ›
Chain: P
Length: 38 amino acids
Theoretical weight: 3.8 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 38 amino acids
Theoretical weight: 3.8 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical:
P06881 (Residues: 83-119; Coverage: 36%)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Molecule details ›
Chain: A
Length: 394 amino acids
Theoretical weight: 45.68 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: G-protein alpha subunit
Length: 394 amino acids
Theoretical weight: 45.68 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: P63092 (Residues: 1-394; Coverage: 100%)
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Molecule details ›
Chain: B
Length: 350 amino acids
Theoretical weight: 38.53 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Length: 350 amino acids
Theoretical weight: 38.53 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Molecule details ›
Chain: G
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: GGL domain
Structure domains: Transducin (heterotrimeric G protein), gamma chain
Length: 71 amino acids
Theoretical weight: 7.86 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: P59768 (Residues: 1-71; Coverage: 100%)
Sequence domains: GGL domain
Structure domains: Transducin (heterotrimeric G protein), gamma chain
Calcitonin gene-related peptide type 1 receptor
Molecule details ›
Chain: R
Length: 490 amino acids
Theoretical weight: 56.27 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 490 amino acids
Theoretical weight: 56.27 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: Q16602 (Residues: 22-461; Coverage: 100%)
Sequence domains:
Receptor activity-modifying protein 1
Molecule details ›
Chain: E
Length: 149 amino acids
Theoretical weight: 17.07 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: Receptor activity modifying family
Length: 149 amino acids
Theoretical weight: 17.07 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: O60894 (Residues: 27-148; Coverage: 100%)
Sequence domains: Receptor activity modifying family
