› 6e83

Solution NMR

Solution structure of ZZZ3 ZZ domain in complex with histone H3 tail

Released:
DOI: 10.2210/pdb6e83/pdb
PDB entry 6e83 coloured by chain, ensemble of 20 models, front view.
PDB entry 6e83 coloured by chain, ensemble of 20 models, side view.
PDB entry 6e83 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation.
Mi W, Zhang Y, Lyu J, Wang X, Tong Q, Peng D, Xue Y, Tencer AH, Wen H, Li W, Kutateladze TG, Shi X
Nat Commun 9 3759 (2018)
PMID: 30217978

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159421 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ZZ-type zinc finger-containing protein 3 Chain: B
Molecule details ›
Chain: B
Length: 64 amino acids
Theoretical weight: 7.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IYH5 (Residues: 816-874; Coverage: 7%)
Gene name: ZZZ3
Sequence domains: Zinc finger, ZZ type
Histone H3.1 Chain: A
Molecule details ›
Chain: A
Length: 12 amino acids
Theoretical weight: 1.31 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 2-13; Coverage: 9%)
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 73%
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

7 review citations

Dynamic modules of the coactivator SAGA in eukaryotic transcription.
Cheon et al. (2020)
6 more

2 mentions without citation

Molecular and structural mechanisms of ZZ domain-mediated cargo selection by Nbr1.
Wang et al. (2021)
1 more