6edu

Electron Microscopy
4.06Å resolution

B41 SOSIP.664 in complex with soluble CD4 (D1-D2), the co-receptor mimicking antibody 21c and the broadly neutralizing antibody 8ANC195

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 21-mer (preferred)
PDBe Complex ID:
PDB-CPX-207658 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (12 distinct):
Transmembrane protein gp41 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 153 amino acids
Theoretical weight: 17.36 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Cricetulus griseus
UniProt:
  • Canonical: B3UEZ6 (Residues: 516-668; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein
Envelope glycoprotein gp160 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 516 amino acids
Theoretical weight: 57.7 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Cricetulus griseus
UniProt:
  • Canonical: B3UES2 (Residues: 29-509; Coverage: 56%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
T-cell surface glycoprotein CD4 Chains: G, H, I
Molecule details ›
Chains: G, H, I
Length: 185 amino acids
Theoretical weight: 20.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01730 (Residues: 26-208; Coverage: 42%)
Gene name: CD4
Sequence domains:
21c Fab VH domain Chains: J, L, N
Molecule details ›
Chains: J, L, N
Length: 231 amino acids
Theoretical weight: 24.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
21c Fab VL domain Chains: K, M, O
Molecule details ›
Chains: K, M, O
Length: 217 amino acids
Theoretical weight: 22.82 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
8ANC195 G52K5 Fab VH domain Chains: P, R, T
Molecule details ›
Chains: P, R, T
Length: 244 amino acids
Theoretical weight: 26.13 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
8ANC195 G52K5 Fab VL domain Chains: Q, S, U
Molecule details ›
Chains: Q, S, U
Length: 215 amino acids
Theoretical weight: 23.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.06Å
Relevant EMDB volumes: EMD-9038
Expression systems:
  • Cricetulus griseus
  • Homo sapiens