› 6eim

X-ray diffraction
1.43Å resolution

Human STK10 bound to GW683134A

Released:
DOI: 10.2210/pdb6eim/pdb
PDB entry 6eim coloured by chain, front view.
PDB entry 6eim coloured by chain, side view.
PDB entry 6eim coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sorrell FJ, Berger B-T, Salah E, von Delft F, Bountra C, Arrowsmith C, Edwards AM, Knapp S, Elkins JM

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131760 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 302 amino acids
Theoretical weight: 34.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O94804 (Residues: 18-317; Coverage: 31%)
Gene names: LOK, STK10
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand EDO 5 x EDO
Ligand B6E 2 x B6E
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P212121
Unit cell:
a: 49.468Å b: 99.812Å c: 125.839Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.155 0.154 0.174
Expression system: Escherichia coli

Quick links