› 6elr

X-ray diffraction
1.8Å resolution

Human jak1 kinase domain in complex with compound 7

Released:
DOI: 10.2210/pdb6elr/pdb
PDB entry 6elr coloured by chain, front view.
PDB entry 6elr coloured by chain, side view.
PDB entry 6elr coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Read JA

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149968 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 301 amino acids
Theoretical weight: 34.64 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23458 (Residues: 854-1154; Coverage: 26%)
Gene names: JAK1, JAK1A, JAK1B
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand BFK 2 x BFK
Ligand NA 1 x NA
1 modified residue:
Ligand PTR 4 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 42.991Å b: 174.093Å c: 44.968Å
α: 90° β: 94.37° γ: 90°
R-values:
R R work R free
0.182 0.181 0.205
Expression system: Spodoptera frugiperda

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