› 6eot

X-ray diffraction
3.5Å resolution

DPP8 - SLRFLYEG, space group 19

Released:
DOI: 10.2210/pdb6eot/pdb
PDB entry 6eot coloured by chain, front view.
PDB entry 6eot coloured by chain, side view.
PDB entry 6eot coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Ross B, Krapp S, Augustin M, Kierfersauer R, Arciniega M, Geiss-Friedlander R, Huber R
Proc Natl Acad Sci U S A 115 E1437-E1445 (2018)
PMID: 29382749

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159023 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dipeptidyl peptidase 8 Chains: A, B, D, G, I, K
Molecule details ›
Chains: A, B, D, G, I, K
Length: 898 amino acids
Theoretical weight: 103.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6V1X1 (Residues: 1-898; Coverage: 100%)
Gene names: DPP8, DPRP1, MSTP097, MSTP135, MSTP141
Sequence domains:
Small ubiquitin-related modifier 1 Chains: C, E, F, H, J, L
Molecule details ›
Chains: C, E, F, H, J, L
Length: 8 amino acids
Theoretical weight: 985 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P63165 (Residues: 61-68; Coverage: 8%)
Gene names: OK/SW-cl.43, SMT3C, SMT3H3, SUMO1, UBL1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 148.159Å b: 264.675Å c: 268.937Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.262
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

2 review citations

Structures and functions of the inflammasome engine.
Wang et al. (2021)
1 more

1 mention without citation

Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer.
Ross et al. (2018)