6eqb

X-ray diffraction
2.81Å resolution

HLA class I histocompatibility antigen

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-209040 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 814 Da
Source organism: Homo sapiens
Expression system: Not provided
High Affinity Mel5 TCR, alpha chain Chain: D
Molecule details ›
Chain: D
Length: 196 amino acids
Theoretical weight: 21.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
High Affinity Mel5 TCR, beta chain Chain: E
Molecule details ›
Chain: E
Length: 244 amino acids
Theoretical weight: 27.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P43
Unit cell:
a: 120.771Å b: 120.771Å c: 82.247Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.183 0.251
Expression systems:
  • Escherichia coli
  • Not provided