› 6ero

X-ray diffraction
1.75Å resolution

Structure of human TFB2M

Released:
DOI: 10.2210/pdb6ero/pdb
PDB entry 6ero coloured by chain, front view.
PDB entry 6ero coloured by chain, side view.
PDB entry 6ero coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis of Mitochondrial Transcription Initiation.
Hillen HS, Morozov YI, Sarfallah A, Temiakov D, Cramer P
Cell 171 1072-1081.e10 (2017)
PMID: 29149603

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190626 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dimethyladenosine transferase 2, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 313 amino acids
Theoretical weight: 35.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H5Q4 (Residues: 63-267, 295-396; Coverage: 78%)
Gene names: NS5ATP5, TFB2M
Sequence domains: Ribosomal RNA adenine dimethylase

Ligands and Environments

2 bound ligands:
Ligand CL 2 x CL
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 43.95Å b: 165.65Å c: 44.73Å
α: 90° β: 97.97° γ: 90°
R-values:
R R work R free
0.193 0.192 0.214
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

33 review citations

Organization and regulation of gene transcription.
Cramer P. (2019)
32 more

4 mentions without citation

Structural basis of mitochondrial transcription.
Hillen et al. (2018)
3 more