› 6eub

X-ray diffraction
2.3Å resolution

The fibrinogen-like domain of human Angptl4

Released:
DOI: 10.2210/pdb6eub/pdb
PDB entry 6eub coloured by chain, front view.
PDB entry 6eub coloured by chain, side view.
PDB entry 6eub coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease.
Biterova E, Esmaeeli M, Alanen HI, Saaranen M, Ruddock LW
Sci Rep 8 6752 (2018)
PMID: 29713054

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189822 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ANGPTL4 C-terminal chain Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 26.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli str. K-12 substr. MDS42
UniProt:
  • Canonical: Q9BY76 (Residues: 184-406; Coverage: 59%)
Gene names: ANGPTL4, ARP4, HFARP, PGAR, PP1158, PSEC0166, UNQ171/PRO197
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 1PE 1 x 1PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2221
Unit cell:
a: 133.02Å b: 133.77Å c: 39.63Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.254
Expression system: Escherichia coli str. K-12 substr. MDS42

Quick links

Citations

7 review citations

Lipoprotein Lipase and Its Regulators: An Unfolding Story.
Wu et al. (2021)
6 more

5 mentions without citation

Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease.
Biterova et al. (2018)
4 more