› 6ew1

X-ray diffraction
2.31Å resolution

Crystal structure of the Filamin A Ig-like domains 3-5 mutant P637Q

Released:
DOI: 10.2210/pdb6ew1/pdb
PDB entry 6ew1 coloured by chain, front view.
PDB entry 6ew1 coloured by chain, side view.
PDB entry 6ew1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A.
Haataja TJK, Bernardi RC, Lecointe S, Capoulade R, Merot J, Pentikäinen U
Structure 27 102-112.e4 (2019)
PMID: 30344108

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149204 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Filamin-A Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 31.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21333 (Residues: 478-766; Coverage: 11%)
Gene names: FLN, FLN1, FLNA
Sequence domains: Filamin/ABP280 repeat
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-3
Spacegroup: P65
Unit cell:
a: 60.721Å b: 60.721Å c: 163.178Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.246 0.245 0.273
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Structure and Function of Filamin C in the Muscle Z-Disc.
Mao et al. (2020)
5 other articles

1 mention without citation

Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A.
Haataja et al. (2019)