› 6ez8

Electron Microscopy
4Å resolution

Human Huntingtin-HAP40 complex structure

Released:
DOI: 10.2210/pdb6ez8/pdb
PDB entry 6ez8 coloured by chain, front view.
PDB entry 6ez8 coloured by chain, side view.
PDB entry 6ez8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The cryo-electron microscopy structure of huntingtin.
Guo Q, Cheng J, Seefelder M, Engler T, Pfeifer G, Oeckl P, Otto M, Moser F, Maurer M, Pautsch A, Baumeister W, Fernández-Busnadiego R, Kochanek S
Nature 555 117-120 (2018)
PMID: 29466333
Related structures: EMD-3984

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150024 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Huntingtin Chain: A
Molecule details ›
Chain: A
Length: 3138 amino acids
Theoretical weight: 347.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P42858 (Residues: 1-3142; Coverage: 100%)
Gene names: HD, HTT, IT15
Sequence domains:
40-kDa huntingtin-associated protein Chain: B
Molecule details ›
Chain: B
Length: 371 amino acids
Theoretical weight: 39.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P23610 (Residues: 1-371; Coverage: 100%)
Gene names: F8A1, F8A2, F8A3

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-3984
Expression system: Homo sapiens

Quick links

Citations

24 review citations

Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities.
Tabrizi et al. (2020)
23 more

12 mentions without citation

The Tiny Drosophila Melanogaster for the Biggest Answers in Huntington's Disease.
Rosas-Arellano et al. (2018)
11 more