Function and Biology Details
Reactions catalysed:
Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form C1s (EC 3.4.21.42).
Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Complement subcomponent heavy (preferred)
PDBe Complex ID:
PDB-CPX-133186 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (5 distinct):
Complement C1r subcomponent heavy chain
Molecule details ›
Chains: A, C
Length: 291 amino acids
Theoretical weight: 33.12 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Sequence domains:
Length: 291 amino acids
Theoretical weight: 33.12 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical:
P00736 (Residues: 18-308; Coverage: 42%)
Sequence domains:
Complement C1s subcomponent heavy chain
Molecule details ›
Chains: B, D
Length: 277 amino acids
Theoretical weight: 31.24 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Sequence domains:
Length: 277 amino acids
Theoretical weight: 31.24 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical: P09871 (Residues: 16-292; Coverage: 41%)
Sequence domains:
Ligands and Environments
No modified residues
Experiments and Validation Details
X-ray source:
DIAMOND BEAMLINE I04-1
Spacegroup:
P212121
Expression system: Cricetulus griseus
