› 6f1d

X-ray diffraction
1.95Å resolution

CUB2 domain of C1r

Released:
DOI: 10.2210/pdb6f1d/pdb
PDB entry 6f1d coloured by chain, front view.
PDB entry 6f1d coloured by chain, side view.
PDB entry 6f1d coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the C1r-C1s interaction of the C1 complex of complement activation.
Almitairi JOM, Venkatraman Girija U, Furze CM, Simpson-Gray X, Badakshi F, Marshall JE, Schwaeble WJ, Mitchell DA, Moody PCE, Wallis R
Proc Natl Acad Sci U S A 115 768-773 (2018)
PMID: 29311313

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form C1s (EC 3.4.21.42).
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133182 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement C1r subcomponent heavy chain Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 13.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00736 (Residues: 191-307; Coverage: 17%)
Gene name: C1R
Sequence domains: CUB domain
Structure domains: Spermadhesin, CUB domain

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 44.688Å b: 50.459Å c: 69.209Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.173 0.202
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Complement in neurological disorders and emerging complement-targeted therapeutics.
Dalakas et al. (2020)
7 more

1 mention without citation

Structure of the C1r-C1s interaction of the C1 complex of complement activation.
Almitairi et al. (2018)