› 6f1v

Electron Microscopy
3.4Å resolution

C terminal region of the dynein heavy chains in the dynein tail/dynactin/BICDR1 complex

Released:
DOI: 10.2210/pdb6f1v/pdb
PDB entry 6f1v coloured by chain, front view.
PDB entry 6f1v coloured by chain, side view.
PDB entry 6f1v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
Nature 554 202-206 (2018)
PMID: 29420470
Related structures: EMD-4170

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171971 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytoplasmic dynein 1 heavy chain 1 Chains: f, m
Molecule details ›
Chains: f, m
Length: 1186 amino acids
Theoretical weight: 136.79 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14204 (Residues: 1-1186; Coverage: 26%)
Gene names: DHC1, DNCH1, DNCL, DNECL, DYHC, DYNC1H1, KIAA0325
Sequence domains: Dynein heavy chain, N-terminal region 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-4170
Expression system: Spodoptera frugiperda

Quick links

Citations

20 review citations

The cytoplasmic dynein transport machinery and its many cargoes.
Reck-Peterson et al. (2018)
19 more