› 6f1y

Electron Microscopy
3.4Å resolution

Dynein light intermediate chain region of the dynein tail/dynactin/BICDR1 complex

Released:
DOI: 10.2210/pdb6f1y/pdb
PDB entry 6f1y coloured by chain, front view.
PDB entry 6f1y coloured by chain, side view.
PDB entry 6f1y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
Nature 554 202-206 (2018)
PMID: 29420470
Related structures: EMD-4171

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128873 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cytoplasmic dynein 1 heavy chain 1 Chain: f
Molecule details ›
Chain: f
Length: 328 amino acids
Theoretical weight: 33.12 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14204 (Residues: 780-927; Coverage: 3%)
Gene names: DHC1, DNCH1, DNCL, DNECL, DYHC, DYNC1H1, KIAA0325
Cytoplasmic dynein 1 light intermediate chain 2 Chain: j
Molecule details ›
Chain: j
Length: 337 amino acids
Theoretical weight: 38.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43237 (Residues: 37-373; Coverage: 69%)
Gene names: DNCLI2, DYNC1LI2, LIC2
Sequence domains: Dynein light intermediate chain (DLIC)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-4171
Expression system: Spodoptera frugiperda

Quick links

Citations

20 review citations

The cytoplasmic dynein transport machinery and its many cargoes.
Reck-Peterson et al. (2018)
19 more

1 mention without citation

Structure of the dynein-2 complex and its assembly with intraflagellar transport trains.
Toropova et al. (2019)