› 6f62

X-ray diffraction
2.07Å resolution

Crystal structure of the SYCP1 N-terminal head-to-head assembly in open conformation

Released:
DOI: 10.2210/pdb6f62/pdb
PDB entry 6f62 coloured by chain, front view.
PDB entry 6f62 coloured by chain, side view.
PDB entry 6f62 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly.
Dunce JM, Dunne OM, Ratcliff M, Millán C, Madgwick S, Usón I, Davies OR
Nat Struct Mol Biol 25 557-569 (2018)
PMID: 29915389

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172286 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptonemal complex protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 109 amino acids
Theoretical weight: 12.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15431 (Residues: 101-206; Coverage: 11%)
Gene names: SCP1, SYCP1

Ligands and Environments

2 bound ligands:
Ligand CL 2 x CL
Ligand MPD 2 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Unit cell:
a: 65.67Å b: 37.31Å c: 108.52Å
α: 90° β: 106.66° γ: 90°
R-values:
R R work R free
0.227 0.226 0.244
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Let's get physical - mechanisms of crossover interference.
von Diezmann et al. (2021)
5 more

2 mentions without citation

Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly.
Dunce et al. (2018)
1 more