› 6f63

X-ray diffraction
2.15Å resolution

Crystal structure of the SYCP1 C-terminal back-to-back assembly

Released:
DOI: 10.2210/pdb6f63/pdb
PDB entry 6f63 coloured by chain, front view.
PDB entry 6f63 coloured by chain, side view.
PDB entry 6f63 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly.
Dunce JM, Dunne OM, Ratcliff M, Millán C, Madgwick S, Usón I, Davies OR
Nat Struct Mol Biol 25 557-569 (2018)
PMID: 29915389

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172286 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptonemal complex protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 98 amino acids
Theoretical weight: 11.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15431 (Residues: 676-770; Coverage: 10%)
Gene names: SCP1, SYCP1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2
Unit cell:
a: 233.42Å b: 42.85Å c: 43.69Å
α: 90° β: 93.61° γ: 90°
R-values:
R R work R free
0.22 0.219 0.253
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Let's get physical - mechanisms of crossover interference.
von Diezmann et al. (2021)
5 more

2 mentions without citation

Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly.
Dunce et al. (2018)
1 more