› 6f7b

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitotic checkpoint serine/threonine-protein kinase BUB1 Chain: A
Molecule details ›
Chain: A
Length: 361 amino acids
Theoretical weight: 41.48 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O43683 (Residues: 726-1085; Coverage: 33%)
Gene names: BUB1, BUB1L
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CVQ 1 x CVQ
Ligand MG 1 x MG
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Unit cell:
a: 50.497Å b: 60.093Å c: 124.469Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.198 0.254
Expression system: Trichoplusia ni

Quick links

Citations

5 review citations

Cell cycle control in cancer.
Matthews et al. (2022)
4 more

1 mention without citation

Robust Identification of Differential Gene Expression Patterns from Multiple Transcriptomics Datasets for Early Diagnosis, Prognosis, and Therapies for Breast Cancer.
Tuly et al. (2023)