› 6fax

X-ray diffraction
2.99Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210898 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Lob 7.4 light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Lob 7.4 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 240 amino acids
Theoretical weight: 25.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Tumor necrosis factor receptor superfamily member 5 Chain: R
Molecule details ›
Chain: R
Length: 173 amino acids
Theoretical weight: 19.19 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P25942 (Residues: 21-193; Coverage: 67%)
Gene names: CD40, TNFRSF5
Sequence domains: TNFR/NGFR cysteine-rich region

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P3121
Unit cell:
a: 158.753Å b: 158.753Å c: 93.622Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.185 0.231
Expression system: Homo sapiens

Quick links

Citations

22 review citations

Harnessing innate immunity in cancer therapy.
Demaria et al. (2019)
21 more

3 mentions without citation

Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.
Yu et al. (2018)
2 more