› 6fcz

Electron Microscopy
10Å resolution

Model of gC1q-Fc complex based on 7A EM map

Released:
DOI: 10.2210/pdb6fcz/pdb
PDB entry 6fcz coloured by chain, front view.
PDB entry 6fcz coloured by chain, side view.
PDB entry 6fcz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement.
Ugurlar D, Howes SC, de Kreuk BJ, Koning RI, de Jong RN, Beurskens FJ, Schuurman J, Koster AJ, Sharp TH, Parren PWHI, Gros P
Science 359 794-797 (2018)
PMID: 29449492
Related structures: EMD-4232

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-136126 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Complement C1q subcomponent subunit A Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 14.91 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02745 (Residues: 112-244; Coverage: 60%)
Gene name: C1QA
Sequence domains: C1q domain
Complement C1q subcomponent subunit B Chain: B
Molecule details ›
Chain: B
Length: 132 amino acids
Theoretical weight: 15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02746 (Residues: 119-250; Coverage: 58%)
Gene name: C1QB
Sequence domains: C1q domain
Complement C1q subcomponent subunit C Chain: C
Molecule details ›
Chain: C
Length: 129 amino acids
Theoretical weight: 14.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02747 (Residues: 117-245; Coverage: 59%)
Gene names: C1QC, C1QG
Sequence domains: C1q domain
Immunoglobulin gamma-1 heavy chain Chains: H, K
Molecule details ›
Chains: H, K
Length: 216 amino acids
Theoretical weight: 24.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DOX5 (Residues: 234-449; Coverage: 48%)
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 10Å
Relevant EMDB volumes: EMD-4232
Expression system: Homo sapiens

Quick links

Citations

22 review citations

Fc-Engineering for Modulated Effector Functions-Improving Antibodies for Cancer Treatment.
Liu et al. (2020)
21 more

9 mentions without citation

Antibody-mediated complement activation in pathology and protection.
Goldberg et al. (2020)
8 more