› 6fdz

X-ray diffraction
2.55Å resolution

Unc-51-Like Kinase 3 (ULK3) In Complex With Momelotinib

Released:
DOI: 10.2210/pdb6fdz/pdb
PDB entry 6fdz coloured by chain, front view.
PDB entry 6fdz coloured by chain, side view.
PDB entry 6fdz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mathea S, Salah E, Moroglu M, Scorah A, Pike ACW, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Huber K, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180155 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase ULK3 Chain: U
Molecule details ›
Chain: U
Length: 276 amino acids
Theoretical weight: 31.94 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6PHR2 (Residues: 2-277; Coverage: 59%)
Gene name: ULK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand C87 1 x C87
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P6122
Unit cell:
a: 75.836Å b: 75.836Å c: 214.691Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.234 0.23 0.301
Expression system: Spodoptera frugiperda

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