› 6ffc

Electron Microscopy
3.56Å resolution

Structure of an inhibitor-bound ABC transporter

Released:
DOI: 10.2210/pdb6ffc/pdb
PDB entry 6ffc coloured by chain, front view.
PDB entry 6ffc coloured by chain, side view.
PDB entry 6ffc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Jackson SM, Manolaridis I, Kowal J, Zechner M, Taylor NMI, Bause M, Bauer S, Bartholomaeus R, Bernhardt G, Koenig B, Buschauer A, Stahlberg H, Altmann KH, Locher KP
Nat Struct Mol Biol 25 333-340 (2018)
PMID: 29610494
Related structures: EMD-4256

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194005 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Broad substrate specificity ATP-binding cassette transporter ABCG2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 664 amino acids
Theoretical weight: 73.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UNQ0 (Residues: 2-655; Coverage: 100%)
Gene names: ABCG2, ABCP, BCRP, BCRP1, MXR
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand BWQ 2 x BWQ
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.56Å
Relevant EMDB volumes: EMD-4256
Expression system: Homo sapiens

Quick links

Citations

25 review citations

Cryo-EM in drug discovery: achievements, limitations and prospects.
Renaud et al. (2018)
24 more

29 mentions without citation

Structural and functional diversity calls for a new classification of ABC transporters.
Thomas et al. (2020)
28 more