6ffy

X-ray diffraction
3.9Å resolution

Structure of the mouse SorCS2-NGF complex

Released:
Source organism: Mus musculus

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-134075 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
SorCS2 104 kDa chain Chain: A
Molecule details ›
Chain: A
Length: 972 amino acids
Theoretical weight: 109.12 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9EPR5 (Residues: 116-1077; Coverage: 87%)
Gene name: Sorcs2
Sequence domains:
Beta-nerve growth factor Chains: B, C
Molecule details ›
Chains: B, C
Length: 129 amino acids
Theoretical weight: 14.36 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P01139 (Residues: 122-238; Coverage: 53%)
Gene names: Ngf, Ngfb
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2
Unit cell:
a: 229.755Å b: 117.706Å c: 90Å
α: 90° β: 111.87° γ: 90°
R-values:
R R work R free
0.261 0.258 0.305
Expression system: Homo sapiens